Scientific publications
- Elafibranor improves diet-induced nonalcoholic steatohepatitis associated with heart failure with preserved ejection fraction in Golden Syrian hamsters.
Briand F, Maupoint J, Brousseau E, Breyner N, Bouchet M, Costard C, Leste-Lasserre T, Petitjean M, Chen L, Chabrat A, Richard V, Burcelin R, Dubroca C, Sulpice T. Metabolism. 2021 Jan 11;117:154707.
https://pubmed.ncbi.nlm.nih.gov/33444606/ - Liraglutide shows superior cardiometabolic benefits than lorcaserin in a novel free choice diet-induced obese rat model. Eur J Pharmacol. 2020 Sep 5;882:173316
Briand F, Brousseau E, Maupoint J, Dubroca C, Costard C, Breyner N, Burcelin R, Sulpice T. 2020 Sep 5;882:173316.
https://pubmed.ncbi.nlm.nih.gov/32621913/
- Neuronal NO synthase mediates phenylephrine induced cardiomyocyte hypertrophy through facilitation of NFAT-dependent transcriptional activity.
Loyer X, Dubroca C, Branchereau M, Griffith G, Garcia L, Heymes C. Biochem Biophys Rep. 2019 Mar 11;18:100620.
https://www.ncbi.nlm.nih.gov/pubmed/30899802 - Structural evidence for a new elaborate 3D-organization of the cardiomyocyte lateral membrane in adult mammalian cardiac tissues.
Guilbeau-Frugier C, Cauquil M, Karsenty C, Lairez O, Dambrin C, Payré B, Cassard H, Josse C, Seguelas MH, Allart S, Branchereau M, Heymes C, Mandel F, Delisle MB, Pathak A, Dague E, Senard JM, Galés C. Cardiovasc Res. 2019 May 1;115(6):1078-1091.
https://www.ncbi.nlm.nih.gov/pubmed/30329023 - Deciphering biased inverse agonism of cangrelor and ticagrelor at P2Y12 receptor.
Garcia C, Maurel-Ribes A, Nauze M, N’Guyen D, Martinez LO, Payrastre B, Senard JM, Galés C, Pons V. Cell Mol Life Sci. 2019 Feb;76(3):561-576.
https://www.ncbi.nlm.nih.gov/pubmed/30406277 - G protein stoichiometry dictates biased agonism through distinct receptor-G protein partitioning.
Onfroy L, Galandrin S, Pontier SM, Seguelas MH, N’Guyen D, Senard JM, Galés C. Sci Rep. 2017 Aug 11;7(1):7885.
https://www.ncbi.nlm.nih.gov/pubmed/28801617 - Cardioprotective Angiotensin-(1-7) Peptide Acts as a Natural-Biased Ligand at the Angiotensin II Type 1 Receptor.
Galandrin S, Denis C, Boularan C, Marie J, M’Kadmi C, Pilette C, Dubroca C, Nicaise Y, Seguelas MH, N’Guyen D, Banères JL, Pathak A, Senard JM, Galés C. Hypertension. 2016 Dec;68(6):1365-1374.
https://www.ncbi.nlm.nih.gov/pubmed/27698068 - Paracrine nitric oxide induces expression of cardiac sarcomeric proteins in adult progenitor cells through soluble guanylyl cyclase/cyclic-guanosine monophosphate and Wnt/β-catenin inhibition.
De Pauw A, Massion P, Sekkali B, Andre E, Dubroca C, & al.. Cardiovasc Res. 2016 Oct;112(1):478-90
https://www.ncbi.nlm.nih.gov/pubmed/27520736 - Delineating biased ligand efficacy at 7TM receptors from an experimental perspective. Galandrin S, Onfroy L, Poirot MC, Senard JM, Galés C. Int J Biochem Cell Biol. 2016 Aug;77(Pt B):251-63
https://www.ncbi.nlm.nih.gov/pubmed/27107932 - Dual agonist occupancy of AT1-R-α2C-AR heterodimers results in atypical Gs-PKA signaling.
Bellot M, Galandrin S, Boularan C, Matthies HJ, Despas F, Denis C, Javitch J,Mazères S, Sanni SJ, Pons V, Seguelas MH, Hansen JL, Pathak A, Galli A, Senard JM, Galés C. Nat Chem Biol. 2015
https://www.ncbi.nlm.nih.gov/pubmed/25706338 - Atomic force and electron microscopic-based study of sarcolemmal surface of living cardiomyocytes unveils unexpected mitochondrial shift in heart failure.
Dague E, Genet G, Lachaize V, Guilbeau-Frugier C, Fauconnier J, Mias C, Payré B, Chopinet L, Alsteens D, Kasas S, Severac C, Thireau J, Heymes C, Honton B, Lacampagne A, Pathak A, Senard JM, Galés C. J Mol Cell Cardiol. 2014 Sept; 74:162-72.
https://www.ncbi.nlm.nih.gov/pubmed/24839910 - Dosage-dependent regulation of cell proliferation and adhesion through dual β2-adrenergic receptor/cAMP signals.
Bruzzone A, Saulière A, Finana F, Senard JM, Lüthy I, Galés C. FASEB J. 2014 Mar;28(3):1342-54
https://www.ncbi.nlm.nih.gov/pubmed/24308976 - Cardiac fibroblasts regulate sympathetic nerve sprouting and neurocardiac synapse stability.
Mias C, Coatrieux C, Denis C, Genet G, Seguelas MH, Laplace N, Rouzaud-Laborde C, Calise D, Parini A, Cussac D, Pathak A, Senard JM, Galés C. PLoS One. 2013 Nov 14;8(11):e79068
https://www.ncbi.nlm.nih.gov/pubmed/24244423 - High-intensity interval exercise improves vagal tone and decreases arrhythmias in chronic heart failure.
Guiraud T, Labrunee M, Gaucher-Cazalis K, Despas F, Meyer P, Bosquet L, Gales C, Vaccaro A, Bousquet M, Galinier M, Senard JM, Pathak A. Med Sci Sports Exerc. 2013 Oct;45(10):1861-7
https://www.ncbi.nlm.nih.gov/pubmed/23591293 - Cardiac dysfunction in rats with dietary-induced insulin resistance associated with pharmacologically-induced dyslipidemia.
Tanguy S, Toufektsian MC, Grauzam S, de Leiris J, Ghezzi C, Boucher F, Sulpice T. Curr Pharm Des. 2013;19(39):6906-11
https://www.ncbi.nlm.nih.gov/pubmed/23590153 - Deciphering biased-agonism complexity reveals a new active AT1 receptor entity.
Saulière A, Bellot M, Paris H, Denis C, Finana F, Hansen JT, Altié MF, Seguelas MH, Pathak A, Hansen JL, Senard JM, Galés C. Nat Chem Biol. 2012, Jul;8(7):622-30.
https://www.ncbi.nlm.nih.gov/pubmed/22634635 - Ephrin-B1 is a novel specific component of the lateral membrane of the cardiomyocyte and is essential for the stability of cardiac tissue architecture cohesion.
Genet G, Guilbeau-Frugier C, Honton B, Dague E, Schneider MD, Coatrieux C, Calise D, Cardin C, Nieto C, Payré B, Dubroca C, Marck P, Heymes C, Dubrac A, Arvanitis D, Despas F, Altié MF, Seguelas MH, Delisle MB, Davy A, Senard JM, Pathak A, Galés C. Circ Res. 2012, Mar 2;110(5):688-700.
https://www.ncbi.nlm.nih.gov/pubmed/22302788 - Probing Heterotrimeric G Protein Activation: Applications to Biased Ligands.
Denis C, Saulière A, Galandrin S, Senard JM, Galés C. Curr Pharm Des. 2012;18(2):128-44.
https://www.ncbi.nlm.nih.gov/pubmed/22229559 - Role of matrix metalloproteinases in early hypertensive vascular remodeling.
Flamant M, Placier S, Dubroca C, Esposito B, Lopes I, Chatziantoniou C, Tedgui A, Dussaule JC, Lehoux S. Hypertension. 2007 Jul;50(1):212-8.
https://www.ncbi.nlm.nih.gov/pubmed/17515450 - Adrenomedullin inhibits adipogenesis under transcriptional control of insulin.
Harmancey R, Senard JM, Rouet P, Pathak A, Smih F. Diabetes. 2007 Mar;56(3):553-63.
https://www.ncbi.nlm.nih.gov/pubmed/17327422 - NMR and cDNA array analysis prior to heart failure reveals an increase of unsaturated lipids, a glutamine/glutamate ratio decrease and a specific transcriptome adaptation in obese rat heart.
Roncalli J, Smih F, Desmoulin F, Dumonteil N, Harmancey R, Hennig S, Perez L, Pathak A, Galinier M, Massabuau P, Malet-Martino M, Senard JM, Rouet P. J Mol Cell Cardiol. 2007 Mar; 42(3):526-39.
https://www.ncbi.nlm.nih.gov/pubmed/17222424 - AT1 receptor blockade prevents cardiac dysfunction after myocardial infarction in rats.
Berthonneche C, Sulpice T, Tanguy S, O’Connor S, Herbert JM, Janiak P, de Leiris J, Boucher F. Cardiovasc Drugs Ther. 2005 Aug;19(4):251-9.
https://www.ncbi.nlm.nih.gov/pubmed/16193242 - The vasoactive peptide adrenomedullin is secreted by adipocytes and inhibits lipolysis through NO-mediated beta-adrenergic agonist oxidation.
Harmancey R, Senard JM, Pathak A, Desmoulin F, Claparols C, Rouet P, Smih F. FASEB J. 2005 Jun; 19(8):1045-7.
https://www.ncbi.nlm.nih.gov/pubmed/15788445 - Involvement of RhoA/Rho kinase pathway in myogenic tone in the rabbit facial vein.
Dubroca C, You D, Lévy BI, Loufrani L, Henrion D. Hypertension. 2005 May;45(5):974-9.
https://www.ncbi.nlm.nih.gov/pubmed/15837833 - Insulin downregulates M(2)-muscarinic receptors in adult rat atrial cardiomyocytes: a link between obesity and cardiovascular complications.
Pathak A, Smih F, Galinier M, Verwaerde P, Rouet P, Philip-Couderc P, Montastruc JL, Senard JM. Int J Obes (Lond). 2005 Feb;29(2):176-82
https://www.ncbi.nlm.nih.gov/pubmed/15505636 - Impaired vascular mechanotransduction in a transgenic mouse model of CADASIL arteriopathy. Dubroca C, Lacombe P, Domenga V, Maciazek J, Levy B, Tournier-Lasserve E, Joutel A, Henrion D. Stroke. 2005 Jan;36(1):113-7.
https://www.ncbi.nlm.nih.gov/pubmed/15569862 - Kinetic analysis of cardiac transcriptome regulation during chronic high-fat diet in dogs.
Philip-Couderc P, Smih F, Hall JE, Pathak A, Roncalli J, Harmancey R, Massabuau P, Galinier M, Verwaerde P, Senard JM, Rouet P. Physiol Genomics. 2004 Sep 16; 19(1):32-40.
https://www.ncbi.nlm.nih.gov/pubmed/15226482 - New insights into the pathological role of TNF-alpha in early cardiac dysfunction and subsequent heart failure after infarction in rats.
Berthonneche C, Sulpice T, Boucher F, Gouraud L, de Leiris J, O’Connor SE, Herbert JM, Janiak P. Am J Physiol Heart Circ Physiol. 2004 Jul;287(1):H340-50.
https://www.ncbi.nlm.nih.gov/pubmed/15210453 - Absence of dystrophin in mice reduces NO-dependent vascular function and vascular density: total recovery after a treatment with the aminoglycoside gentamicin.
Loufrani L, Dubroca C, You D, Li Z, Levy B, Paulin D, Henrion D. Arterioscler Thromb Vasc Biol. 2004 Apr;24(4):671-6.
https://www.ncbi.nlm.nih.gov/pubmed/14751810 - Adrenomedullin upregulates M2-muscarinic receptors in cardiomyocytes from P19 cell line.
Buys S, Smih F, Pathak A, Philip-Couderc P, Verwaerde P, Montastruc JL, Rouet P, Senard JM. Br J Pharmacol. 2003 Jul;139(6):1219-27.
https://www.ncbi.nlm.nih.gov/pubmed/12871842 - High isoproterenol doses are required to activate beta3-adrenoceptor-mediated functions in dogs.
Pelat M, Verwaerde P, Galitzky J, Lafontan M, Berlan M, Senard JM, Montastruc JL. J Pharmacol Exp Ther. 2003 Jan; 304(1):246-53
https://www.ncbi.nlm.nih.gov/pubmed/12490598 - Cardiac transcriptome analysis in obesity-related hypertension.
Philip-Couderc P, Smih F, Pelat M, Vidal C, Verwaerde P, Pathak A, Buys S, Galinier M, Senard JM, Rouet P. Hypertension. 2003 Mar; 41(3):414-21.
https://www.ncbi.nlm.nih.gov/pubmed/12623937 - Role of peripheral benzodiazepine receptors in mitochondrial, cellular, and cardiac damage induced by oxidative stress and ischemia-reperfusion.
Leducq N, Bono F, Sulpice T, Vin V, Janiak P, Fur GL, O’Connor SE, Herbert JM. J Pharmacol Exp Ther. 2003 Sep;306(3):828-37.
https://www.ncbi.nlm.nih.gov/pubmed/12928523 - Alpha2 –adrenoceptor function in arterial hypertension associated with obesity in dogs fed a high-fat diet.
J Hypertens. 2002 May; 20(5):957-64.
https://www.ncbi.nlm.nih.gov/pubmed/12011657 - Fluoxetine-induced pressor response in freely moving rats: a role for vasopressin and sympathetic tone.
Pelat M, Verwaerde P, Tran MA, Montastruc JL, Senard JM. Fundam Clin Pharmacol. 2000 Sep-Oct; 14(5):443-51.
https://www.ncbi.nlm.nih.gov/pubmed/11129084 - Impaired atrial M(2)-cholinoceptor function in obesity-related hypertension.
Pelat M, Verwaerde P, Merial C, Galitzky J, Berlan M, Montastruc JL, Senard JM. Hypertension. 1999 Nov;34(5):1066-72.
https://www.ncbi.nlm.nih.gov/pubmed/10567183
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